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Principal Investigator

Issam Ben-Sahra, Ph.D.

Associate Professor of Biochemistry and Molecular Genetics

Issam received his Master's research degree in Genetics, Development, and Immunity from the Côte d'Azur University in France in 2007. He obtained his Ph.D. from the same university in December 2010, where he studied the molecular and cellular effects of metabolic perturbators on cancer cells and tumor growth under the supervision of Dr. Frederic Bost. In 2011, Issam joined the laboratory of Prof. Brendan D. Manning in the department of Genetics and Complex Diseases at Harvard T.H. Chan School of Public Health. There, he combined his knowledge in metabolism and signaling pathways to understand how mTORC1 drives anabolic cell growth and proliferation. In January 2017, Issam joined Northwestern University/Feinberg School of Medicine as an Assistant Professor of Biochemistry and Molecular Genetics. In September 2023, Issam was granted tenure and promoted to Associate Professor.

Lab Manager

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Heather Carr, Ph.D.

Lab Manager

Heather completed her Ph.D. in Chemistry at the University of Wisconsin. She then pursued a post-doctoral fellowship at the University of Utah, focusing on metal metabolism in yeast. Later, she joined Dr. Jeffrey Frost’s team at the University of Texas Health Science Center at Houston, where she investigated the mechanisms of breast cancer cell migration and invasion. Heather also explored protein-protein interactions in GPCR signaling in neuroendocrine tumor cell lines. In June 2023, Heather joined the Ben-Sahra lab as the Research Lab Manager. Heather brings her expertise in lab management and organization to her current role. She is interested in studying the alterations in cellular metabolism in physiological and pathological states.


Ph.D., 2000, University of Wisconsin--Madison, U.S.A.



Umakant Sahu, Ph.D.

Postdoctoral fellow

Umakant did his M. Sc. in Biotechnology at the University of Allahabad (Allahabad, India). He earned his Ph.D. degree from the Indian Institute of Science (Bangalore, India) where he studied the transcriptional metabolic regulation of non-fermentable carbon compounds in a methylotrophic yeast, Pichia pastoris. In the Ben-Sahra laboratory, Umakant is interested in understanding the regulation of nucleotide metabolism in cancer cells. 


Ph.D., 2017, Indian Institute of Science, Bangalore, India

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Mushtaq Nengroo, Ph.D.

Postdoctoral fellow

Mushtaq obtained his Ph.D. degree at the Jawaharlal Nehru University in New Delhi, India. His doctoral studies at the Central Drug Research Institute (CSIR) focused on the role of CXCR4 in tumor growth and metastasis in the context of chemotherapy resistance. In the Ben-Sahra and Mendillo labs, Mushtaq is using CRISPR-Cas9 screening to untangle the metabolic reprogramming and vulnerabilities of tumor cells



Ph.D., Nov 2021, (CSIR-SRF), Jawaharlal Nehru University, New Delhi, India

Olivia Vidal-Cruchez, Ph.D.

Postdoctoral fellow

Olivia obtained her Ph.D. degree at Côte d'Azur University in Nice, France. Her doctoral studies at the Institute for Research on Cancer and Aging (IRCAN) enabled the identification a novel mechanism of drug tolerance to MEK inhibitors (MEKi) that involves Processing Bodies (PBs). In the Ben-Sahra laboratory, Olivia is interested in understanding how signaling and cellular metabolism control cell biomass production and contribute to oncogenic transformation.


Ph.D., Dec 2021, Côte d'Azur University, Nice, France


Konrad T. Sawicki, M.D./Ph.D.

Postdoctoral fellow, Physician Scientist Training Program

Konrad received his bachelor’s degree in Biochemistry with Honors from the University of Michigan in 2010. He subsequently obtained his M.D. and Ph.D. degrees at Northwestern University, where he studied cellular and mitochondrial iron regulation in the heart and post-transcriptional regulation of hepatic metabolism under Dr. Hossein Ardehali. In 2017, Konrad joined the Physician Scientist Training Program at Northwestern University and has completed his internal medicine residency and the majority of his clinical cardiology fellowship. Konrad is conducting his post-doctoral research in the laboratory of Dr. Elizabeth McNally, in close collaboration with the Ben-Sahra laboratory. Konrad is interested in understanding how mitochondrial membrane proteins regulate cardiac metabolism and the regulation of myocardial substrate utilization in cardiovascular health and disease.



M.D., Northwestern University, Feinberg School of Medicine

Ph.D., Northwestern University, Feinberg School of Medicine



Anthony Pulvino

Ph.D. Student (IBIS program)

Anthony Pulvino is interested in host-microbe interactions and how the microbiome has influenced the evolution of primate hosts. His thesis is centered around how the host genome of non-human primates responds to different metabolic products of their (literally) wild intestinal microbiome. Anthony is co-supervised by Drs. Katherine Amato and Issam Ben-Sahra. In the Ben-Sahra lab, Anthony investigates the evolutionary dynamics of the microbiome and metabolome across human and non-human primate species.

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