Eunus S. Ali, Ph.D.
After obtaining his Master degree in medicinal & protein chemistry at Stockholm University Arrhenius Laboratory, Eunus earned his Ph.D. in biochemistry & cell biology at Flinders University School of Medicine (Adelaide, Australia) where he identified and proposed a model where low cellular Ca2+ levels help synthesize more lipids in fatty liver cells. In the Ben-Sahra laboratory, Eunus is interested in the molecular interface between signal transduction pathways and cellular metabolism in cancer.
Ph.D., 2016, Flinders University School of Medicine, Australia
M.S., 2010, Stockholm University, Sweden
Shireman JM, Atashi F*, Lee G*, Ali ES*, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS, James CD, Stupp R, Kumthekar P, Horbinski CM, Ben-Sahra I, Ahmed AU.De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma. Brain. 2021 May 7;144(4):1230-1246. *Equal contribution.
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Molecular Cell. 2021 Mar 17:S1097-2765(21)00177-5. doi: 10.1016/j.molcel.2021.03.009.
Ali ES*, Sahu U*, Villa E, O’Hara BP, Gao P, Beaudet P, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. 2020 May 28:S1097-2765(20)30302-6. doi:10.1016/j.molcel.2020.05.001. * Equal contribution.
Ali ES, Rychkov GY, Barritt GJ. Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma. Cell Calcium. 2019 Sep;82:102057. doi: 10.1016/j.ceca.2019.102057.
Villa E*, Ali ES*, Sahu U*, Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers (Basel). 2019 May 17;11(5):688. doi: 10.3390/cancers11050688. * Equal contribution.
Ali ES, Petrovsky N. Calcium Signaling As a Therapeutic Target for Liver Steatosis. Trends Endocrinol Metab. 2019 Apr;30(4):270-281. doi: 10.1016/j.tem.2019.02.005. Epub 2019 Mar 5.
Tam KC, Ali E, Hua J, Chataway T, Barritt GJ. Evidence for the Interaction of peroxiredoxin-4 With the Store-Operated Calcium Channel Activator STIM1 in Liver Cells. Cell Calcium. 2018 Sep;74:14-28. doi: 10.1016/j.ceca.2018.05.002.
Ali ES, Rychkov GY, Barritt GJ.Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease. Adv Exp Med Biol. 2017;993:595-621. doi: 10.1007/978-3-319-57732-6_30.
Ali, E. S., Hua, J., Wilson, C., Tallis, G. A., Zhou, F. H., Rychkov, G. and Barritt, G. J. (2016) The GLP-1 analogue exendin-4 reverses inhibited SOCE in steatotic hepatocytes., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863(9):2135-46.
Ali, E. S., Rajapaksha, H., Carr, J.M. and Petrovsky, N. (2016). Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. Antiviral Research, 133:14-22. (Subsequent review of Masters thesis)
Wilson, C. H.*, Ali, E. S.*, Scrimgour, N., Martin, A., Tallis, G. A., Rychkov, G. Y. and Barritt, G. J. (2015) Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C dependent mechanism., Biochemical Journal, 466(2):379-90. [*Equal first-authors].
Lundborg, M., Ali, E. and Widmalm, G. (2013) An in silico virtual screening study for the design of norovirus inhibitors: fragment-based molecular docking and binding free energy calculations, Carbohydrate Research, 378:133-138.