Eunus S. Ali, Ph.D.

Postdoctoral fellow

After obtaining his Master degree in medicinal & protein chemistry at Stockholm University Arrhenius Laboratory, Eunus earned his Ph.D. in biochemistry & cell biology at Flinders University School of Medicine (Adelaide, Australia) where he identified and proposed a model where low cellular Ca2+ levels help synthesize more lipids in fatty liver cells. In the Ben-Sahra laboratory, Eunus is interested in the molecular interface between signal transduction pathways and cellular metabolism in cancer.

Education:

Ph.D., 2016, Flinders University School of Medicine, Australia

M.S., 2010, Stockholm University, Sweden

Ali ES*, Sahu U*, Villa E, O’Hara BP, Gao P, Beaudet P, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. 2020 May 28:S1097-2765(20)30302-6. doi:10.1016/j.molcel.2020.05.001. * Equal contribution.

Ali ES, Rychkov GY, Barritt GJ. Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma. Cell Calcium. 2019 Sep;82:102057. doi: 10.1016/j.ceca.2019.102057.

Villa E*, Ali ES*, Sahu U*, Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers (Basel). 2019 May 17;11(5):688. doi: 10.3390/cancers11050688. * Equal contribution.

 

Ali ES, Petrovsky N. Calcium Signaling As a Therapeutic Target for Liver Steatosis. Trends Endocrinol Metab. 2019 Apr;30(4):270-281. doi: 10.1016/j.tem.2019.02.005. Epub 2019 Mar 5.

Tam KC, Ali E, Hua  J, Chataway T, Barritt GJ. Evidence for the Interaction of peroxiredoxin-4 With the Store-Operated Calcium Channel Activator STIM1 in Liver Cells. Cell Calcium. 2018 Sep;74:14-28. doi: 10.1016/j.ceca.2018.05.002.
 

Ali ES, Rychkov GY, Barritt GJ.Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease. Adv Exp Med Biol. 2017;993:595-621. doi: 10.1007/978-3-319-57732-6_30.

Ali, E. S., Hua, J., Wilson, C., Tallis, G. A., Zhou, F. H., Rychkov, G. and Barritt, G. J. (2016) The GLP-1 analogue exendin-4 reverses inhibited SOCE in steatotic hepatocytes., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863(9):2135-46.


Ali, E. S., Rajapaksha, H., Carr, J.M. and Petrovsky, N. (2016). Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens. Antiviral Research, 133:14-22. (Subsequent review of Masters thesis)


Wilson, C. H.*, Ali, E. S.*, Scrimgour, N., Martin, A., Tallis, G. A., Rychkov, G. Y. and Barritt, G. J. (2015) Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C dependent mechanism., Biochemical Journal, 466(2):379-90. [*Equal first-authors].


Lundborg, M., Ali, E. and Widmalm, G. (2013) An in silico virtual screening study for the design of norovirus inhibitors: fragment-based molecular docking and binding free energy calculations, Carbohydrate Research, 378:133-138.