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Brendan P. O'Hara

Brendan was the Research Laboratory Manager of the Ben-Sahra lab from March 2019 to January 2022. His research was geared towards understanding the regulation of signaling and cellular metabolism in cancer cells.

Education:                                                                                                       Master of Biochemistry, UK, 2004

Zerhouni M, Martin AR, Furstoss N, Gutierrez VS, Jaune E, Tekaya N, Beranger GE, Abbe P, Regazzetti C, Amdouni H, Driowya M, Dubreuil P, Luciano F, Jacquel A, Tulic MK, Cluzeau T, O'Hara BP, Ben-Sahra I, Passeron T, Benhida R, Robert G, Auberger P, Rocchi S. Dual covalent inhibition of PKM and IMPDH targets metabolism in cutaneous metastatic melanoma. Cancer Res. 2021 Jun 7:canres.2114.2020. doi: 10.1158/0008-5472.CAN-20-2114.

Villa E
, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
Molecular Cell. 2021 Mar 17:S1097-2765(21)00177-5. doi: 10.1016/j.molcel.2021.03.009.

Ali ES*, Sahu U*, Villa E, O’Hara BP, Gao P, Beaudet P, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. 2020 May 28:S1097-2765(20)30302-6. doi:10.1016/j.molcel.2020.05.001. *Equal contribution.

Harwood FC, Klein Geltink RI, O'Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, Grosveld GC. ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer. Sci Adv. 2018 Sep 12;4(9): eaar3938

Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T. The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. J Biol Chem. 2006 Mar 17;281(11):7228-36