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Brendan P. O'Hara

Research Lab Manager

Brendan earned a Master degree in biochemistry at the University of Bath, UK. Brendan is the Research Laboratory Manager and has expertise encompassing a broad range of techniques related to the fields of biochemistry, molecular biology, genetics, and cell biology. He has also critical knowledge in laboratory and budget management. Brendan joined the Ben-Sahra lab at Northwestern University in March 2019. His research is geared towards understanding the regulation of signaling and cellular metabolism in cancer cells.

Education:                                                                                                           Master of Biochemistry, UK, 2004

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Molecular Cell. 2021 Mar 17:S1097-2765(21)00177-5. doi: 10.1016/j.molcel.2021.03.009.

Ali ES*, Sahu U*, Villa E, O’Hara BP, Gao P, Beaudet P, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. 2020 May 28:S1097-2765(20)30302-6. doi:10.1016/j.molcel.2020.05.001. *Equal contribution.

Harwood FC, Klein Geltink RI, O'Hara BP, Cardone M, Janke L, Finkelstein D, Entin I, Paul L, Houghton PJ, Grosveld GC. ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer. Sci Adv. 2018 Sep 12;4(9): eaar3938

Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T. The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. J Biol Chem. 2006 Mar 17;281(11):7228-36